Phosgene → Methyl 2-[(chlorocarbonyl)amino]benzoate
反応式
[C:1]([O:10][CH3:11])(=[O:9])[C:2]1[C:3](=[CH:5][CH:6]=[CH:7][CH:8]=1)[NH2:4].[C:12](Cl)([Cl:14])=[O:13]>ClCCl>[Cl:14][C:12]([NH:4][C:3]1[CH:5]=[CH:6][CH:7]=[CH:8][C:2]=1[C:1]([O:10][CH3:11])=[O:9])=[O:13]参加物
4
実験手順
A solution of methyl anthranilate (6.0 g) in dichloromethane (50 ml) was added dropwise over 15 min to a 0° solution of phosgene (20% in toluene, 100 ml) in dichloromethane (50 ml) under a nitrogen atmosphere. After addition the resulting opaque solution was stirred at room temperature for 5 h before concentrating to dryness to give the title compound as a white solid (8.0 g), m.p. 80°-82°.
後処理
- additionAfter addition the resulting opaque solution
- concentrationbefore concentrating to dryness
出典と根拠
- ORDレコード
- ord-8f81fb5f9c9b4d1785c3bf64f43bab1c
- 出典データセット
- uspto-grants-1997_04
- 特許番号
- US05618827
反応ノート
読み込み中…