関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Ethyl Acetate | HCID 8857 | — |
| 反応物 | Potassium Carbonate | HCID 11430 | — |
| 反応物 | 2-Methoxy-5-nitrophenol | HCID 69471 | — |
| 反応物 | 1-(2-Chloroethyl)pyrrolidine hydrochloride | HCID 81668 | — |
| 溶媒 | Water | HCID 962 | — |
| 溶媒 | Dimethylformamide | HCID 6228 | — |
| 生成物 | 1-(2-(2-Methoxy-4-nitrophenoxy)ethyl)pyrrolidine | HCID 17989355 | — |
反応手順
Potassium carbonate (3.3 g) was added to a solution of 4-nitroguaiacol (1.0 g) and 1-(2-chloroethyl)pyrrolidine hydrochloride (1.0 g) in DMF (20.0 mL), and the mixture was heated at 100° C. overnight. The reaction mixture was then mixed with ethyl acetate and water, and the organic phase was washed twice with water, dried over sodium sulfate and concentrated. The product with the molecular weight of 266.3 (C13H18N2O4) was obtained in this way; MS (ESI): 267 (M+H+).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US08853208B2 |
|---|
| 出典データセット | uspto-grants-2014_10 |
|---|
| ORD ID | ord-25ff1ee11c9f40fc841bf714f6d2c747 |
|---|
| 出典メモ | uspto-grants-2014_10 |
|---|
