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Hydrochloric Acid → 4-Trifluoromethylpyridinium hydrochloride
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Hydrochloric Acid | HCID 313 | — |
| 反応物 | 2-Chloro-4-(trifluoromethyl)pyridine | HCID 144958 | — |
| 触媒 | Palladium | HCID 23938 | — |
| 溶媒 | Acetic Acid | HCID 176 | — |
| 生成物 | 4-Trifluoromethylpyridinium hydrochloride | HCID 19961898 | — |
反応手順
A solution of 2-chloro-4-trifluoromethylpyridine (11.6 g) in glacial acetic acid (70 ml), containing 10% palladium on carbon (2.4 g, 21% (w/w)) was hydrogenated at 40 psi for 4 h. Concentrated hydrochloric acid (20 ml) was added and hydrogenation continued for a further 1 h. The catalyst was filtered off and the filtrate evaporated in vacuo to afford 4-trifluoromethylpyridinium hydrochloride.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05618812 |
| 出典データセット | uspto-grants-1997_04 |
| ORD ID | ord-c04524e8cfc64b38be348babfd49ccb1 |
| 出典メモ | uspto-grants-1997_04 |