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1,1-Dibromoethane → 2-Ethoxycarbonylimino-3-(3-trifluoromethylphenyl)thiazolidine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 1,1-Dibromoethane | HCID 11201 | — |
| 反応物 | Potassium Carbonate | HCID 11430 | — |
| 反応物 | Ethyl N-{[3-(trifluoromethyl)phenyl]carbamothioyl}carbamate | HCID 971062 | — |
| 溶媒 | Acetone | HCID 180 | — |
| 生成物 | 2-Ethoxycarbonylimino-3-(3-trifluoromethylphenyl)thiazolidine | HCID 54225833 | 83.1% |
反応手順
A solution of N-(3-trifluoromethylphenyl)-N'-ethoxycarbonylthiourea (1.8 g), dibromoethane (1.29 g) and anhydrous potassium carbonate (2.6 g) in acetone (20 ml) was refluxed for 5 hours. The solvent was removed by distillation, and the residue was extracted with diethyl ether. The extract was washed with water, dried over anhydrous magnesium sulfate and concentrated under reduced pressure. The residue was recrystallized from a mixture of hexane and ethanol to give 1.63 g of 2-ethoxycarbonylimino-3-(3-trifluoromethylphenyl)thiazolidine. m.p., 75.8° C.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05244863 |
| 出典データセット | uspto-grants-1993_09 |
| ORD ID | ord-fa8d09f785da43d08f3fafc57bc6778e |
| 出典メモ | uspto-grants-1993_09 |