Hydrochloric Acid → 1-(3-Methoxypyridin-2-yl)-[1,4]diazepane dihydrochloride
反応式
C(OC([N:8]1[CH2:14][CH2:13][CH2:12][N:11]([C:15]2[C:20]([O:21][CH3:22])=[CH:19][CH:18]=[CH:17][N:16]=2)[CH2:10][CH2:9]1)=O)(C)(C)C.[ClH:23].O1CCOCC1>CO>[ClH:23].[ClH:23].[CH3:22][O:21][C:20]1[C:15]([N:11]2[CH2:12][CH2:13][CH2:14][NH:8][CH2:9][CH2:10]2)=[N:16][CH:17]=[CH:18][CH:19]=1参加物
5
実験手順
To 4-(3-methoxypyridin-2-yl)-[1,4]diazepane-1-carboxylic acid tert-butyl ester (335 mg, 1.1 mmol) was added MeOH (3 mL) followed by 4M HCl in dioxane (5 mL, 20 mmol). This was stirred for 15 hours, then concentrated to give the title compound. MS (ES) m/z 208 (M+H+).
後処理
- concentrationconcentrated
出典と根拠
- ORDレコード
- ord-68970de082864fc28415ab1918483439
- 出典データセット
- uspto-grants-2014_10
- 特許番号
- US08853202B2
反応ノート
読み込み中…