Hydrochloric Acid → HCID 66893249、化合物

HRID 532818ノート

反応式

HRID 532818 の反応式
C(OC([N:8]1[CH2:14][CH2:13][CH2:12][N:11]([C:15]2[CH:16]=[C:17]([CH2:25][CH3:26])[CH:18]=[C:19]3[C:24]=2[N:23]=[CH:22][CH:21]=[CH:20]3)[CH2:10][CH2:9]1)=O)(C)(C)C.[ClH:27]>CO.O1CCOCC1>[ClH:27].[ClH:27].[N:11]1([C:15]2[CH:16]=[C:17]([CH2:25][CH3:26])[CH:18]=[C:19]3[C:24]=2[N:23]=[CH:22][CH:21]=[CH:20]3)[CH2:12][CH2:13][CH2:14][NH:8][CH2:9][CH2:10]1

参加物

5

反応物 2

HCID 313Hydrochloric AcidHCID 59366199HCID 59366199、化合物

生成物 1

HCID 66893249HCID 66893249、化合物

試薬・触媒・溶媒 2

HCID 887Methanol溶媒HCID 312751,4-Dioxane溶媒

実験手順

4-(6-Ethylquinolin-8-yl)-[1,4]-diazepan-1-carboxylic acid tert-butyl ester (1.0 g, 1.0 equiv) was dissolved in MeOH (5 mL) and 1.0 M HCl in 1,4-dioxane (10 mL) was added to the mixture. After stirring at room temperature for 1 hour, the mixture was concentrated to dryness to afford the title compound (1.0 g). MS (ES) m/z 256.1 (M+H+).

後処理

  1. concentrationthe mixture was concentrated to dryness

出典と根拠

ORDレコード
ord-6cebc267509349bab0ffba49543e5844
出典データセット
uspto-grants-2014_10
特許番号
US08853202B2

反応ノート

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