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2,5-Dimethylphenyl isocyanate → 1-Cyclopentyl-3-(2,5-dimethyl-phenyl)-7-methoxy-1H-pyrimido[5,4-c]quinoline-2,4-dione
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 2,5-Dimethylphenyl isocyanate | HCID 98605 | — |
| 反応物 | 4-Cyclopentylamino-8-methoxy-quinoline-3-carboxylic acid ethyl ester | HCID 67249718 | — |
| 生成物 | 1-Cyclopentyl-3-(2,5-dimethyl-phenyl)-7-methoxy-1H-pyrimido[5,4-c]quinoline-2,4-dione | HCID 58329457 | 34.6% |
反応手順
1-Cyclopentyl-3-(2,5-dimethyl-phenyl)-7-methoxy-1H-pyrimido[5,4-c]quinoline-2,4-dione (46 mg) was prepared from 4-cyclopentylamino-8-methoxy-quinoline-3-carboxylic acid ethyl ester (0.32 mmol) and 1-isocyanato-2,5-dimethyl-benzene (0.48 mmol) following general procedure C. LCMS: m/z 416 [M+1]+.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08853226B2 |
| 出典データセット | uspto-grants-2014_10 |
| ORD ID | ord-607afa6389e94990b40b8873d42193bb |
| 出典メモ | uspto-grants-2014_10 |