化工社化工社 化学情報印刷レポート · 研究参考用
Ethyl 3-(bromophenyl)acetate → Ethyl 4-(3-bromophenyl)butanoate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Ethyl 3-(bromophenyl)acetate | HCID 11470552 | — |
| 反応物 | Ethyl 4-(4-bromophenyl)butanoate | HCID 12870375 | — |
| 生成物 | Ethyl 4-(3-bromophenyl)butanoate | HCID 11492759 | — |
反応手順
Employing the same general multistep preparation as for ethyl 4-(4-bromophenyl)butanoate (Compound C), 60 g (246 mmol) of ethyl (3-bromophenyl)acetate (Compound B) was converted into the title compound (oil) using 255 ml (255 mmol) of diisobutylaluminum hydride (DIBAL-H, 1M in hexane), 85.8 g (250 mmol) of (carbethoxymethylene) triphenylphosphorane and 1.7 g of 10% Pd/C.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05618943 |
| 出典データセット | uspto-grants-1997_04 |
| ORD ID | ord-baf3153e0aee4c7b907510d1c5905477 |
| 出典メモ | uspto-grants-1997_04 |