Potassium Hydroxide → 5-tert-Butylaminocarbonyl-2-methylthiothiazole-4-carboxylic acid

HRID 5334

反応式

HRID 5334 の反応式
[OH-].[K+].[C:3]([NH:7][C:8]([C:10]1[S:14][C:13]([S:15][CH3:16])=[N:12][C:11]=1[C:17]([O:19]CC)=[O:18])=[O:9])([CH3:6])([CH3:5])[CH3:4]>O.O.C(O)C>[C:3]([NH:7][C:8]([C:10]1[S:14][C:13]([S:15][CH3:16])=[N:12][C:11]=1[C:17]([OH:19])=[O:18])=[O:9])([CH3:6])([CH3:4])[CH3:5]

参加物

5

反応物 2

HCID 14797Potassium HydroxideHCID 150095734-Ethoxycarbonyl-2-methylthiothiazole-5-carboxylic acid-tert-butylamide

生成物 1

HCID 150095705-tert-Butylaminocarbonyl-2-methylthiothiazole-4-carboxylic acid

試薬・触媒・溶媒 2

HCID 962Water溶媒HCID 19096565Water ethanol溶媒

実験手順

0.82 g (14.6 mmol) of potassium hydroxide in 10 ml of water was added to a solution of 4.00 g (13.2 mmol) of 4-ethoxycarbonyl-2-methylthiothiazole-5-carboxylic acid-tert-butylamide in 50 ml of water/ethanol (2:1), and the mixture was refluxed for 2 hours. The solvent mixture was then removed under reduced pressure and the residue was taken up in 50 ml of water and acidified with concentrated hydrochloric acid. The precipitated product was filtered off and dried.

後処理

  1. temperaturethe mixture was refluxed for 2 hours
  2. customThe solvent mixture was then removed under reduced pressure
  3. filtrationThe precipitated product was filtered off
  4. customdried

出典と根拠

ORDレコード
ord-2edd7bfaf0f643ea9042f3b3d6c043f5
出典データセット
uspto-grants-1993_09
特許番号
US05244867

関連ノート

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