Acetic Acid → HCID 178497322、化合物

HRID 533412ノート

反応式

HRID 533412 の反応式
[OH:1][C:2]1[C:11]2[C:6](=[CH:7][CH:8]=[C:9]([C:12]([O:14][CH3:15])=[O:13])[CH:10]=2)[N:5]=[CH:4][CH:3]=1.[Cl:16]N1C(=O)CCC1=O.C(O)(=O)C>O>[Cl:16][C:3]1[CH:4]=[N:5][C:6]2[C:11]([C:2]=1[OH:1])=[CH:10][C:9]([C:12]([O:14][CH3:15])=[O:13])=[CH:8][CH:7]=2

参加物

5

反応物 3

HCID 176Acetic AcidHCID 31398ChlorosuccinimideHCID 178497323HCID 178497323、化合物

生成物 1

HCID 178497322HCID 178497322、化合物収率 88%

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

A mixture of methyl 4-hydroxyquinoline-6-carboxylate (2.07 g), N-chlorosuccinimide (1.36 g), and acetic acid (56 mL) was stirred at room temperature for one day. The reaction mixture was diluted with water, and then, the precipitate was collected by filtration to obtain methyl 3-chloro-4-hydroxyquinoline-6-carboxylate (2.13 g).

後処理

  1. filtrationthe precipitate was collected by filtration

出典と根拠

ORDレコード
ord-6b1b42788d7b4d80a849a9ab49c16cbe
出典データセット
uspto-grants-2014_10
特許番号
US08853242B2

反応ノート

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