Potassium Cyanide → 2-(2,3-Dihydro-1,4-benzodioxin-2-yl)acetonitrile

HRID 533441ノート

反応式

HRID 533441 の反応式
[C-:1]#[N:2].[K+].Br[CH2:5][CH:6]1[O:11][C:10]2[CH:12]=[CH:13][CH:14]=[CH:15][C:9]=2[O:8][CH2:7]1>CS(C)=O.O>[C:1]([CH2:5][CH:6]1[O:11][C:10]2[CH:12]=[CH:13][CH:14]=[CH:15][C:9]=2[O:8][CH2:7]1)#[N:2]

参加物

5

反応物 2

HCID 9032Potassium CyanideHCID 983332-Bromomethyl-1,4-benzodioxane

生成物 1

HCID 2675312-(2,3-Dihydro-1,4-benzodioxin-2-yl)acetonitrile

試薬・触媒・溶媒 2

HCID 679Dimethyl Sulfoxide溶媒HCID 962Water溶媒

実験手順

Potassium cyanide (2.05 g, 31.5 mmol) was added to 2-bromomethyl-(2,3dihydrobenzo[1,4]dioxine) (6.87 g, 30 mmol) in DMSO (90 mL) and stirred at ambient temperature for 20 h. The reaction mixture was then diluted with water (250 mL) and extracted twice with diethyl ether. The diethyl ether was washed with water, then washed twice with brine, dried (Na2SO4) and evaporated in vacuo to yield 2-cyanomethyl-(2,3dihydrobenzo[1,4]dioxine) as a white solid.

後処理

  1. extractionextracted twice with diethyl ether
  2. washThe diethyl ether was washed with water
  3. washwashed twice with brine
  4. dry with materialdried (Na2SO4)
  5. customevaporated in vacuo

出典と根拠

ORDレコード
ord-9d456cc913874f81b605e55f1449c306
出典データセット
uspto-grants-2014_10
特許番号
US08853263B2

反応ノート

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