化工社化工社 化学情報印刷レポート · 研究参考用
Formaldehyde → L-Leucine, N-((1,1-dimethylethoxy)carbonyl)-
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Formaldehyde | HCID 712 | — |
| 反応物 | L-Leucine | HCID 6106 | — |
| 反応物 | L-Leucine, N-((1,1-dimethylethoxy)carbonyl)- | HCID 83170 | — |
| 生成物 | L-Leucine, N-((1,1-dimethylethoxy)carbonyl)- | HCID 83170 | — |
| 生成物 | tert-butyl N-[(2S)-4-methyl-1-oxopentan-2-yl]carbamate | HCID 104275 | — |
| 生成物 | Boc-Trp | HCID 44424848 | — |
反応手順
Leu-psi -Tpi-BHA resin is made by reacting Boc-Leu-psi -Trp-BHA resin with formaldehyde in accordance with the procedures as follows: Boc-Leu-psi -Trp-BHA resin is obtained from 1.0 g BHA resin (0.9 m mode NH2 g) with coupling Boc-Trp and Boc-Leu-CHO successively by the method indicated in Operation I and Operation II. 10 ml. DMF containing 1% acetic acid is added to the above peptide resin and then reacted with 1 ml 10% formaldehyde at room temperature for 60 minutes and washed with DMF, MeOH and DCM.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05244883 |
| 出典データセット | uspto-grants-1993_09 |
| ORD ID | ord-918dffba71544237accb80156ad6bdb6 |
| 出典メモ | uspto-grants-1993_09 |