関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Hydrogen Cyanide | HCID 768 | — |
| 反応物 | Methyl Methacrylate | HCID 6658 | — |
| 反応物 | Potassium Cyanide | HCID 9032 | — |
| 溶媒 | N-methyl-2-pyrrolidone | HCID 13387 | — |
| 生成物 | Methyl Methacrylate | HCID 6658 | — |
| 生成物 | 2-Cyano-2-methyl-propanoic acid methyl ester | HCID 10964510 | — |
反応手順
A 500 milliliter (hereinafter abbreviated to "mL") flask equipped with a stirrer, a thermometer and two dropping funnels was charged with 203 g of N-methylpyrrolidone and 1.35 g of potassium cyanide, and to the content in the flask were added dropwise 40 g of prussic acid and 163 g of methyl methacrylate over a period of 4 hours, while the content was maintained at a temperature of 120° C. After the completion of the dropwise addition, the content was maintained at 120° C. for 2 hours to complete the reaction. As a result, methyl cyanoisobutyrate was formed at a conversion of methyl methacrylate (MMA) of 88.3% and at a selectivity of 98.1% based on the reacted MMA.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US05618953 |
|---|
| 出典データセット | uspto-grants-1997_04 |
|---|
| ORD ID | ord-f1580a895d3643059add5c06253fd208 |
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| 出典メモ | uspto-grants-1997_04 |
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