Hydrogen iodide → N,N-dimethyl-2-methyl-3-(3-hydroxyphenyl)valeramide
反応式
[CH3:1][N:2]([CH3:18])[C:3](=[O:17])[CH:4]([CH3:16])[CH:5]([C:8]1[CH:13]=[CH:12][CH:11]=[C:10]([O:14]C)[CH:9]=1)[CH2:6][CH3:7].I>>[CH3:18][N:2]([CH3:1])[C:3](=[O:17])[CH:4]([CH3:16])[CH:5]([C:8]1[CH:13]=[CH:12][CH:11]=[C:10]([OH:14])[CH:9]=1)[CH2:6][CH3:7]参加物
3
実験手順
The steps are: add compound 7 into a reaction flask, add hydroiodic acid, perform heating and reflux for 5 hours; detect the reaction process by TLC; after that, cool the resultant to the room temperature, pour it to an alkaline solution to make the pH become 9, and perform extraction by ethyl acetate and rinse by water; and recycle the solvent after drying and decompression to obtain a light yellow liquid, N,N-dimethyl-2-methyl-3-(3-hydroxyphenyl) valeramide (compound 9).
後処理
- temperatureperform heating
- temperaturereflux for 5 hours
- additionpour it to an alkaline solution
- extractionextraction by ethyl acetate
- washrinse by water
- customafter drying
出典と根拠
- ORDレコード
- ord-c2f9223da66744f39d6b3ee893b1c5ed
- 出典データセット
- uspto-grants-2014_10
- 特許番号
- US08853393B2
反応ノート
読み込み中…