Aluminium lithium hydride → 3-(3-methoxy-phenyl)-N,N,2-trimethyl pentylamine

HRID 533681ノート

反応式

HRID 533681 の反応式
[H-].[Al+3].[Li+].[H-].[H-].[H-].[CH3:7][N:8]([CH3:24])[C:9](=O)[CH:10]([CH3:22])[CH:11]([C:14]1[CH:19]=[CH:18][CH:17]=[C:16]([O:20][CH3:21])[CH:15]=1)[CH2:12][CH3:13]>CCOCC>[CH3:21][O:20][C:16]1[CH:15]=[C:14]([CH:11]([CH2:12][CH3:13])[CH:10]([CH3:22])[CH2:9][N:8]([CH3:24])[CH3:7])[CH:19]=[CH:18][CH:17]=1

参加物

4

反応物 2

HCID 21226445Aluminium lithium hydrideHCID 67306944Benzenepropanamide, beta-ethyl-3-methoxy-N,N,alpha-trimethyl-

生成物 1

HCID 223770203-(3-methoxy-phenyl)-N,N,2-trimethyl pentylamine収率 85%

試薬・触媒・溶媒 1

HCID 3283Diethyl Ether溶媒

実験手順

The steps are: add anhydrous ether into a reaction flask, and add lithium aluminum hydride under the condition of ice bath; dip compound 7, control the temperature within 10, after the dipping detect the reaction process by TLC; after the reaction is ended, pour the reaction liquid in the ice water slowly, separate the ether layer out, rinse by water, perform drying, and recycle the solvent by decompression to obtain a light yellow liquid, 3-(3-methoxy-phenyl)-N,N,2-trimethyl pentylamine. Yield: 85%.

後処理

  1. additionpour
  2. customseparate the ether layer out,
  3. washrinse by water
  4. customperform drying

出典と根拠

ORDレコード
ord-674a2d66e96a4881858494af3ccc1fb6
出典データセット
uspto-grants-2014_10
特許番号
US08853393B2

反応ノート

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