Acetone → Lurasidone hydrochloride
反応式
CC(C)=O.[CH:5]1[CH:6]=[CH:7][C:8]2[S:13][N:12]=[C:11]([N:14]3[CH2:19][CH2:18][N:17]([CH2:20][C@H:21]4[C@H:26]([CH2:27][N:28]5[C:38](=[O:39])[C@H:37]6[C@H:31]([C@H:32]7[CH2:36][C@@H:35]6[CH2:34][CH2:33]7)[C:29]5=[O:30])[CH2:25][CH2:24][CH2:23][CH2:22]4)[CH2:16][CH2:15]3)[C:9]=2[CH:10]=1.C([O-])(=O)C([O-])=O.[ClH:46]>O>[CH:5]1[CH:6]=[CH:7][C:8]2[S:13][N:12]=[C:11]([N:14]3[CH2:19][CH2:18][N:17]([CH2:20][C@H:21]4[C@H:26]([CH2:27][N:28]5[C:38](=[O:39])[C@H:37]6[C@H:31]([C@H:32]7[CH2:36][C@@H:35]6[CH2:34][CH2:33]7)[C:29]5=[O:30])[CH2:25][CH2:24][CH2:23][CH2:22]4)[CH2:16][CH2:15]3)[C:9]=2[CH:10]=1.[ClH:46]参加物
5
実験手順
A mixture consisting of acetone (280 mL), water (140 mL) and lurasidone oxalate (47 g) is refluxed until dissolved. Concentrated hydrochloric acid (11 mL) is added, and the mixture is cooled at ambient temperature for two hours. The solid is filtered, and 36 g of lurasidone hydrochloride free of impurities exceeding 0.1% is obtained after drying.