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4-Bromophenol → Phenol, 4-(3-pyridinyl)-
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 4-Bromophenol | HCID 7808 | — |
| 反応物 | 3-(Tributylstannyl)pyridine | HCID 3483848 | — |
| 触媒 | HCID 178418476 | HCID 178418476 | — |
| 溶媒 | 1,4-Dioxane | HCID 31275 | — |
| 生成物 | Phenol, 4-(3-pyridinyl)- | HCID 153040 | 60% |
反応手順
26.8 g of 4-bromophenol was taken under protective gas in 1000 ml of dioxane, mixed with 90 g 3-tributylstannylpyridine [preparation according to litt.: Org. Magn. Resonance, 7 (1975), 610] and 11.1 g of bis-(triphenylphosphine)-palladium(II) chloride and refluxed for 15 hours. After concentration by evaporation in a vacuum and purification on silica gel, 15.92 g of the above compound is isolated.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05244886 |
| 出典データセット | uspto-grants-1993_09 |
| ORD ID | ord-7844a06e09664a17934167953fba756b |
| 出典メモ | uspto-grants-1993_09 |