関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Dimethyl Sulfoxide | HCID 679 | — |
| 反応物 | 1,1'-Carbonyldiimidazole | HCID 68263 | — |
| 反応物 | 5-Hydroxypyridine-2-carboxylic acid | HCID 268740 | — |
| 反応物 | HCID 178449908 | HCID 178449908 | — |
| 溶媒 | Ethyl Acetate | HCID 8857 | — |
| 生成物 | 6-(3-Isopropyl-[1,2,4]oxadiazol-5-yl)-pyridin-3-ol | HCID 136377300 | — |
反応手順
To DMSO (25 mL) was added 5-hydroxy-pyridine-2-carboxylic acid (1.0 g) and CDI (1.3 g). After 15 minutes N-hydroxy-isobutyramidine (820 mg) was added. After 1 hour the mixture was heated to 90° C. for 1 hour. After the mixture reached room temperature, it was diluted with EA and washed three times with HCl (0.1 M). The organic phase was dried (Na2SO4) and concentrated to provide the title compound. MS ESI+: m/z=206 [M+H]+.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US08853412B2 |
|---|
| 出典データセット | uspto-grants-2014_10 |
|---|
| ORD ID | ord-989f920584734f61b7577085f4131722 |
|---|
| 出典メモ | uspto-grants-2014_10 |
|---|
