Methyl 2-[[3-[4-(5-chloro-2-methoxyphenyl)piperazin-1-yl]propyl]amino]-pyrimidine-4-carboxylate → HCID 178418571、化合物

HRID 5341ノート

反応式

HRID 5341 の反応式
[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([O:28][CH3:29])=[C:6]([N:8]2[CH2:13][CH2:12][N:11]([CH2:14][CH2:15][CH2:16][NH:17][C:18]3[N:23]=[C:22]([C:24](OC)=[O:25])[CH:21]=[CH:20][N:19]=3)[CH2:10][CH2:9]2)[CH:7]=1.[NH2:30][CH2:31][CH2:32][NH:33][C:34]1[NH:35][CH:36]=[CH:37][C:38](=[O:40])[N:39]=1>C(O)CCC>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([O:28][CH3:29])=[C:6]([N:8]2[CH2:9][CH2:10][N:11]([CH2:14][CH2:15][CH2:16][NH:17][C:18]3[N:23]=[C:22]([C:24]([NH:30][CH2:31][CH2:32][NH:33][C:34]4[NH:35][CH:36]=[CH:37][C:38](=[O:40])[N:39]=4)=[O:25])[CH:21]=[CH:20][N:19]=3)[CH2:12][CH2:13]2)[CH:7]=1

参加物

4

反応物 2

HCID 19013272Methyl 2-[[3-[4-(5-chloro-2-methoxyphenyl)piperazin-1-yl]propyl]amino]-pyrimidine-4-carboxylateHCID 178418575HCID 178418575、化合物

生成物 1

HCID 178418571HCID 178418571、化合物

試薬・触媒・溶媒 1

HCID 2631-Butanol溶媒

実験手順

1.89 g of (4.5 mmols) of methyl 2-[[3-[4-(5-chloro-2-methoxyphenyl)piperazin-1-yl]propyl]amino]-pyrimidine-4-carboxylate and 0.77 g (5 mmols) of 2-[(2-aminoethyl)amino]pyrimidin-4(1H)-one in 5 ml of n-butanol are introduced into a 25 ml, round bottomed flask. The mixture is heated at the reflux temperature of the solvent for 15 hours and then the solvent is evaporated under reduced pressure.

後処理

  1. temperatureThe mixture is heated at the reflux temperature of the solvent for 15 hours
  2. customthe solvent is evaporated under reduced pressure

出典と根拠

ORDレコード
ord-682b7c7c9d9d4c65b29faad31f704d69
出典データセット
uspto-grants-1993_09
特許番号
US05244894

反応ノート

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