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Azobisisobutyronitrile → Methyl 4'-(bromomethyl)biphenyl-2-carboxylate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Azobisisobutyronitrile | HCID 6547 | — |
| 反応物 | N-bromobutanimide | HCID 67184 | — |
| 反応物 | (1,1'-Biphenyl)-2-carboxylic acid, 4'-methyl-, methyl ester | HCID 1393873 | — |
| 触媒 | Azobisisobutyronitrile | HCID 6547 | — |
| 溶媒 | Carbon Tetrachloride | HCID 5943 | — |
| 生成物 | Methyl 4'-(bromomethyl)biphenyl-2-carboxylate | HCID 11012181 | 59.6% |
反応手順
2.0 g (8.8 mmol) of methyl 2-(4'-methylphenyl)benzoate, 1.6 g (9.0 mmol) of N-bromosuccinimide and 0.05 g of α,α'-azobis(isobutyronitrile) [another name; 2,2'-azobis(isobutyronitrile)] were dissolved in carbon tetrachloride (110 ml), followed by heating under reflux for 2 hours. The resultant mixture was filtered to remove insolubles, and then vacuum concentration was effected. The residue was recrystallized from a n-hexane/isopropyl ether mixed solvent to give 1.6 g of the title compound (yield; 59%).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05618969 |
| 出典データセット | uspto-grants-1997_04 |
| ORD ID | ord-11522c2bf8264c559cda5831527097e2 |
| 出典メモ | uspto-grants-1997_04 |