2-Bromo-1-(3-bromo-5-(trifluoromethyl)phenyl)ethanone → 2-(3-Bromo-5-(trifluoromethyl)phenyl)-2-oxoethyl methyl succinate

HRID 534850ノート

反応式

HRID 534850 の反応式
Br[CH2:2][C:3]([C:5]1[CH:10]=[C:9]([C:11]([F:14])([F:13])[F:12])[CH:8]=[C:7]([Br:15])[CH:6]=1)=[O:4].[C:16]([O:24]CC(C1C=C(C(F)(F)F)C=C(Cl)C=1)=O)(=[O:23])[CH2:17][CH2:18][C:19]([O:21][CH3:22])=[O:20]>>[C:16]([O:24][CH2:2][C:3]([C:5]1[CH:10]=[C:9]([C:11]([F:14])([F:13])[F:12])[CH:8]=[C:7]([Br:15])[CH:6]=1)=[O:4])(=[O:23])[CH2:17][CH2:18][C:19]([O:21][CH3:22])=[O:20]

参加物

3

反応物 2

HCID 197023342-Bromo-1-(3-bromo-5-(trifluoromethyl)phenyl)ethanoneHCID 667508792-(3-Chloro-5-(trifluoromethyl)phenyl)-2-oxoethyl methyl succinate

生成物 1

HCID 667511272-(3-Bromo-5-(trifluoromethyl)phenyl)-2-oxoethyl methyl succinate収率 60%

実験手順

The title compound was prepared from 2-bromo-1-(3-bromo-5-(trifluoromethyl)phenyl)ethanone (Reference Example 42) by a procedure similar to the one described for 2-(3-chloro-5-(trifluoromethyl)phenyl)-2-oxoethyl methyl succinate (Reference Example 35) to provide 2-(3-bromo-5-(trifluoromethyl)phenyl)-2-oxoethyl methyl succinate (16.05 g, 60%) as a pale yellow oil.

出典と根拠

ORDレコード
ord-44c7431feb7a4b6d8a793a9b81cdb3ee
出典データセット
uspto-grants-2014_10
特許番号
US08853215B2

反応ノート

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