Hydrochloric Acid → HCID 86718436、化合物

HRID 535312ノート

反応式

HRID 535312 の反応式
[I:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]([C:11]2[CH:16]=[CH:15][C:14]([O:17][CH3:18])=[CH:13][CH:12]=2)(O)[CH3:9])=[CH:4][CH:3]=1.C(OC(=O)C)(=O)C.Cl>>[I:1][C:2]1[CH:3]=[CH:4][C:5]([C:8]([C:11]2[CH:12]=[CH:13][C:14]([O:17][CH3:18])=[CH:15][CH:16]=2)=[CH2:9])=[CH:6][CH:7]=1

参加物

4

反応物 3

HCID 313Hydrochloric AcidHCID 7918Acetic AnhydrideHCID 71145508HCID 71145508、化合物

生成物 1

HCID 86718436HCID 86718436、化合物

実験手順

The side chain used in example 5 (1-(4-iodophenyl)-1-(4-methoxyphenyl)ethanol) (1.25 g, 2.86 mmol) was treated with acetic anhydride (13.49 ml, 143 mmol) and HCl conc (1.042 ml, 34.3 mmol) and the reaction mixture was stirred at room temperature overnight. The reaction mixture was filtered. The precipitate was washed well with n-heptane then dried in vacuo to obtain the title compound as white solid.

後処理

  1. filtrationThe reaction mixture was filtered
  2. washThe precipitate was washed well with n-heptane
  3. customthen dried in vacuo

出典と根拠

ORDレコード
ord-cb69c39dcf5b474c9fec2c3cbd483d58
出典データセット
uspto-grants-2014_10
特許番号
US08859535B2

反応ノート

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