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Piperidin-3-ylmethanol → 5,11-Dihydro-11-ethyl-2-[3-(hydroxymethyl)piperidin-1-yl]-4-methyl-6H-dipyrido[3,2-b:2',3'-e][1,4]diazepin-6-one
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Piperidin-3-ylmethanol | HCID 107308 | — |
| 反応物 | Dipyridodiazepinone deriv. 15 | HCID 463144 | — |
| 生成物 | 5,11-Dihydro-11-ethyl-2-[3-(hydroxymethyl)piperidin-1-yl]-4-methyl-6H-dipyrido[3,2-b:2',3'-e][1,4]diazepin-6-one | HCID 19960019 | — |
反応手順
The title compound, m.p. 194°-197° C., was synthesized from 2-chloro-5,11-dihydro-11l-ethyl-4-methyl-6H-dipyrido[3,2-b:2',3'-e][1,4]diazepin-6-one and 3-piperidinemethanol using procedures analogous to those described above, except that the mixture was heated at 170°-180° C. for 2.5 hrs, and the product was crystallized from ethyl acetate.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05620974 |
| 出典データセット | uspto-grants-1997_04 |
| ORD ID | ord-86d277589fbe4f28b104e3eb723a4307 |
| 出典メモ | uspto-grants-1997_04 |