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Dipyridodiazepinone deriv. 15 → 5,11-Dihydro-11-ethyl-2-[(R)-2-(hydroxymethyl)pyrrolidin-1-yl]-4-methyl-6H-dipyrido[3,2-b:2',3'-e][1,4]diazepin-6-one
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Dipyridodiazepinone deriv. 15 | HCID 463144 | — |
| 反応物 | Prolinol, (R)- | HCID 2724541 | — |
| 生成物 | 5,11-Dihydro-11-ethyl-2-[(R)-2-(hydroxymethyl)pyrrolidin-1-yl]-4-methyl-6H-dipyrido[3,2-b:2',3'-e][1,4]diazepin-6-one | HCID 54501304 | — |
反応手順
The title compound, m.p. 239°-242° C., was synthesized from 2-chloro-5,11-dihydro-11-ethyl-4-methyl-6H-dipyrido[3,2-b:2',3'-e][1,4]diazepin-6-one and (R)-(-)-2-pyrrolidinemethanol using procedures analogous to those described above, except that the mixture was heated in a pressure bottle at 160°-170° C. for 2 hrs, and the product was crystallized from chloroform/hexane.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05620974 |
| 出典データセット | uspto-grants-1997_04 |
| ORD ID | ord-080ed352435f45338c219a3be991ad6a |
| 出典メモ | uspto-grants-1997_04 |