3,5-Difluorophenylacetic acid → 2-(3,5-difluorophenyl)-N-[4-(morpholin-4-yl)-1-oxophthalazin-2(1H)-yl]acetamide

関与物質

役割	名称	HCID	仕込み量
反応物	3,5-Difluorophenylacetic acid	HCID 145424	—
反応物	2-amino-4-morpholinophthalazin-1(2H)-one	HCID 70976104	—
生成物	2-(3,5-difluorophenyl)-N-[4-(morpholin-4-yl)-1-oxophthalazin-2(1H)-yl]acetamide	HCID 70976115	—

反応手順

The product of Example 1B and 2-(3,5-difluorophenyl)acetic acid were treated using a method similar to that described in Example 10C to give the title compound. 1H NMR (400 MHz, DMSO-d6) δ ppm 11.55 (s, 1H), 8.31 (dd, J=7.9, 1.3 Hz, 1H), 8.02 (d, J=1.3 Hz, 1H), 7.96-8.01 (m, 1H), 7.88-7.92 (m, 1H), 7.09-7.21 (m, 3H), 3.80-3.83 (m, 4H), 3.73 (s, 2H), 3.08-3.10 (m, 4H); MS (APCI+) M/Z 401 (M+H)+.

情報源と証拠

DOI	10.6084/m9.figshare.5104873.v1
特許番号	US08859549B2
出典データセット	uspto-grants-2014_10
ORD ID	ord-c7103fb6f7694466b0815b998700fa14
出典メモ	uspto-grants-2014_10