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(4-Chlorophenyl)acetic acid → 2-(4-chlorophenyl)-N-[4-(morpholin-4-yl)-1-oxophthalazin-2(1H)-yl]acetamide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | (4-Chlorophenyl)acetic acid | HCID 15880 | — |
| 反応物 | 2-amino-4-morpholinophthalazin-1(2H)-one | HCID 70976104 | — |
| 生成物 | 2-(4-chlorophenyl)-N-[4-(morpholin-4-yl)-1-oxophthalazin-2(1H)-yl]acetamide | HCID 70976179 | — |
反応手順
The product of Example 1B and 2-(4-chlorophenyl)acetic acid were treated using a method similar to that described in Example 10C to give the title compound. 1H NMR (400 MHz, DMSO-d6, Temp=90° C.) δ ppm 11.09-11.16 (m, 1H), 8.30 (d, J=7.1 Hz, 1H), 7.99 (d, J=1.3 Hz, 1H), 7.92-7.96 (m, 1H), 7.84-7.88 (m, 1H), 7.26-7.46 (m, 4H), 3.80-3.83 (m, 4H), 3.64-3.65 (m, 1H), 3.65 (d, J=5.0 Hz, 1H), 3.09-3.13 (m, 4H); MS (APCI+) M/Z 399 (M+H)+.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08859549B2 |
| 出典データセット | uspto-grants-2014_10 |
| ORD ID | ord-7cbd42420baf44a6811bbd5c060607b7 |
| 出典メモ | uspto-grants-2014_10 |