反応式
[CH2:1]([N:3]1[C:9]2[N:10]=[CH:11][CH:12]=[CH:13][C:8]=2[C:7](=[O:14])[NH:6][C:5]2[C:15]([CH3:25])=[CH:16][C:17]([N:19]3[CH2:23][CH2:22][CH:21]([OH:24])[CH2:20]3)=[N:18][C:4]1=2)[CH3:2].[C:26](OC(=O)C)(=[O:28])[CH3:27]>>[C:26]([O:24][CH:21]1[CH2:22][CH2:23][N:19]([C:17]2[CH:16]=[C:15]([CH3:25])[C:5]3[NH:6][C:7](=[O:14])[C:8]4[CH:13]=[CH:12][CH:11]=[N:10][C:9]=4[N:3]([CH2:1][CH3:2])[C:4]=3[N:18]=2)[CH2:20]1)(=[O:28])[CH3:27]参加物
3
実験手順
The title compound, m.p. 188°-189.5° C., was synthesized from 5,11-dihydro-11-ethyl-2-(3- hydroxypyrrolidin-1-yl)-4-methyl-6H-dipyrido[3,2-b:2',3'-e][1,4]diazepin-6-one and acetic anhydride using procedures analogous to those described above. The product was chromatographed over silica gel with ethyl acetate/hexane, and was then crystallized from diisopropyl ether.
出典と根拠
- ORDレコード
- ord-714d3c071a134c8c86a36f750db1d7fb
- 出典データセット
- uspto-grants-1997_04
- 特許番号
- US05620974
関連ノート
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