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4-Mesylphenylacetic acid → 2-[4-(methylsulfonyl)phenyl]-N-[4-(morpholin-4-yl)-1-oxophthalazin-2(1H)-yl]acetamide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 4-Mesylphenylacetic acid | HCID 572345 | — |
| 反応物 | 2-amino-4-morpholinophthalazin-1(2H)-one | HCID 70976104 | — |
| 生成物 | 2-[4-(methylsulfonyl)phenyl]-N-[4-(morpholin-4-yl)-1-oxophthalazin-2(1H)-yl]acetamide | HCID 70975820 | — |
反応手順
The product of Example 1B and 2-(4-(methylsulfonyl)phenyl)acetic acid were treated using a method similar to that described in Example 111 to give the title compound. 1H NMR (500 MHz, DMSO-d6/Deuterium Oxide) δ ppm 8.25-8.35 (m, 1H), 7.97-8.05 (m, 2H), 7.91-7.93 (m, 3H), 7.65-7.67 (m, 2H), 3.83 (s, 3H), 3.82 (d, J=8.4 Hz, 2H), 3.35-3.63 (m, 1H), 3.21 (s, 3H), 3.08-3.11 (m, 4H); MS (ESI+) M/Z 443 (M+H)+.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08859549B2 |
| 出典データセット | uspto-grants-2014_10 |
| ORD ID | ord-fa1831703140426c99e96a0275cb0b85 |
| 出典メモ | uspto-grants-2014_10 |