化工社化工社 化学情報印刷レポート · 研究参考用
2-(1,2-Benzoxazol-3-yl)acetic acid → 2-(1,2-benzoxazol-3-yl)-N-[4-(morpholin-4-yl)-1-oxophthalazin-2(1H)-yl]acetamide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 2-(1,2-Benzoxazol-3-yl)acetic acid | HCID 301729 | — |
| 反応物 | 2-amino-4-morpholinophthalazin-1(2H)-one | HCID 70976104 | — |
| 生成物 | 2-(1,2-benzoxazol-3-yl)-N-[4-(morpholin-4-yl)-1-oxophthalazin-2(1H)-yl]acetamide | HCID 70976162 | — |
反応手順
The product of Example 1B and 2-(1,2-benzoxazol-3-yl)acetic acid were treated using a method similar to that described in Example 111 to give the title compound. 1H NMR (500 MHz, DMSO-d6/D2O) δ 8.32 (d, J=7.9, 1H), 8.07-7.97 (m, 3H), 7.95-7.89 (m, 1H), 7.76 (d, J=8.4, 1H), 7.69 (ddd, J=8.3, 7.0, 1.1, 1H), 7.48-7.41 (m, 1H), 4.19 (s, 2H), 3.86-3.80 (m, 4H), 3.16-3.07 (m, 4H); MS (ESI+) M/Z 406 (M+H)+.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08859549B2 |
| 出典データセット | uspto-grants-2014_10 |
| ORD ID | ord-fa5266894e504c4e98392432ce761991 |
| 出典メモ | uspto-grants-2014_10 |