Mesitylacetic acid → HCID 70976029、化合物

HRID 535589

反応式

HRID 535589 の反応式
[NH2:1][N:2]1[N:11]=[C:10]([N:12]2[CH2:17][CH2:16][O:15][CH2:14][CH2:13]2)[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[C:3]1=[O:18].[CH3:19][C:20]1[CH:25]=[C:24]([CH3:26])[CH:23]=[C:22]([CH3:27])[C:21]=1[CH2:28][C:29](O)=[O:30]>>[N:12]1([C:10]2[C:9]3[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=3)[C:3](=[O:18])[N:2]([NH:1][C:29](=[O:30])[CH2:28][C:21]3[C:20]([CH3:19])=[CH:25][C:24]([CH3:26])=[CH:23][C:22]=3[CH3:27])[N:11]=2)[CH2:17][CH2:16][O:15][CH2:14][CH2:13]1

参加物

3

反応物 2

HCID 78123Mesitylacetic acidHCID 709761042-amino-4-morpholinophthalazin-1(2H)-one

生成物 1

HCID 70976029HCID 70976029、化合物

実験手順

The product of Example 1B and 2-(2,4,6-trimethylphenyl)acetic acid were treated using a method similar to that described in Example 111 to give the title compound. 1H NMR (500 MHz, DMSO-d6/Deuterium Oxide) δ ppm 8.30 (d, J=7.3 Hz, 1H), 8.02 (d, J=8.0 Hz, 1H), 7.96-8.00 (m, 1H), 7.88-7.92 (m, 1H), 6.84-6.85 (bs, 2H), 3.77-3.85 (m, 4H), 3.66 (s, 2H), 3.08-3.13 (m, 4H), 2.31 (s, 6H), 2.21 (s, 3H); MS (ESI+) M/Z 407 (M+H)+.

出典と根拠

ORDレコード
ord-fcceb814cb684bf2979726fc7da9ff01
出典データセット
uspto-grants-2014_10
特許番号
US08859549B2

関連ノート

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