m-Tolylacetic acid → HCID 70975888、化合物

反応式

[NH2:1][N:2]1[N:11]=[C:10]([S:12]([C:15]2[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=2)(=[O:14])=[O:13])[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[C:3]1=[O:21].[CH3:22][C:23]1[CH:24]=[C:25]([CH2:29][C:30](O)=[O:31])[CH:26]=[CH:27][CH:28]=1>>[CH3:22][C:23]1[CH:24]=[C:25]([CH2:29][C:30]([NH:1][N:2]2[N:11]=[C:10]([S:12]([C:15]3[CH:16]=[CH:17][CH:18]=[CH:19][CH:20]=3)(=[O:14])=[O:13])[C:9]3[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=3)[C:3]2=[O:21])=[O:31])[CH:26]=[CH:27][CH:28]=1

参加物

反応物 2

HCID 12121m-Tolylacetic acid

HCID 70975871HCID 70975871、化合物

生成物 1

HCID 70975888HCID 70975888、化合物

実験手順

The product from Example 68B and 2-(3-methylphenyl)acetic acid were processed using a method similar to that described in Example 10C to afford the title compound. 1H NMR (400 MHz, DMSO-d6) δ ppm 11.83 (s, 1H), 8.54-8.57 (m, 1H), 8.37-8.40 (m, 1H), 8.08-8.13 (m, 1H), 7.98-8.03 (m, 3H), 7.78-7.83 (m, 1H), 7.66-7.70 (m, 2H), 7.23 (t, J=7.5

出典と根拠

ORDレコード: ord-0448d2a441374e71a9ac3c34a3eb8ffd
出典データセット: uspto-grants-2014_10
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US08859549B2

反応ノート

読み込み中…

参加物