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HRID 535657作成日：2026年10月25日
Acetic Acid → 7-(4-(2-(5-Acetylpyridin-2-yl)ethyl)piperazin-1-yl)-N,N-dimethylbenzofuran-2-carboxamide
https://huagongshe.com/reaction/535657
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Acetic Acid | HCID 176 | — |
| 反応物 | 1-(6-Vinylpyridin-3-YL)ethanone | HCID 59636720 | — |
| 反応物 | N,N-dimethyl-7-(piperazin-1-yl)benzofuran-2-carboxamide | HCID 59636743 | — |
| 溶媒 | Water | HCID 962 | — |
| 溶媒 | 1-Propanol | HCID 1031 | — |
| 生成物 | 7-(4-(2-(5-Acetylpyridin-2-yl)ethyl)piperazin-1-yl)-N,N-dimethylbenzofuran-2-carboxamide | HCID 59636753 | — |
反応手順
A reaction mixture of N,N-dimethyl-7-(piperazin-1-yl)benzofuran-2-carboxamide (0.078 g, 0.29 mmol) (Example 39d), 1-(6-vinylpyridin-3-yl)ethanone (0.15 g, 1.00 mmol) and acetic acid (0.016 mL, 0.29 mmol) in n-propanol (1.5 mL) and water (0.10 mL) was heated at 69° C. for 2 days. The product was purified by preparative HPLC to give the title compound.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| 特許番号 | US08859534B2 |
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| 出典データセット | uspto-grants-2014_10 |
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| ORD ID | ord-8f282560678f42d1baa474b3dbe156d0 |
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| 出典メモ | uspto-grants-2014_10 |
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