関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Potassium Carbonate | HCID 11430 | — |
| 反応物 | 2,4,6-Trivinylboroxin-Pyridine Complex | HCID 2734806 | — |
| 反応物 | 5-Acetyl-2-bromopyridine | HCID 15668195 | — |
| 触媒 | HCID 178418397 | HCID 178418397 | — |
| 溶媒 | Acetonitrile | HCID 6342 | — |
| 生成物 | 1-(6-Vinylpyridin-3-YL)ethanone | HCID 59636720 | — |
反応手順
The reaction mixture of 1-(6-bromopyridin-3-yl)ethanone (0.68 g, 3.41 mmol), 2,4,6-trivinyl-1,3,5,2,4,6-trioxatriborinane:pyridine (1:1) (0.57 g, 2.39 mmol), potassium carbonate (0.85 g, 6.14 mmol), and Pd(Ph3P)4 (0.16 g, 0.14 mmol) in acetonitrile (10 mL) was degassed with argon for 5 minutes. Then it was heated in the microwave for 30 min at 115° C. The organic phase was removed using a pipette, dried (MgSO4), filtered and concentrated and purified by flash chromatography (SiO2; heptane/EtOAc, gradient 20-80%). Yield: 0.36 g (72%).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US08859534B2 |
|---|
| 出典データセット | uspto-grants-2014_10 |
|---|
| ORD ID | ord-c90ffbba73da4c56b85a66e8591d4592 |
|---|
| 出典メモ | uspto-grants-2014_10 |
|---|
