Methylparaben → Methyl 4-(benzyloxy)benzoate

HRID 535985

反応式

HRID 535985 の反応式
[OH:1][C:2]1[CH:11]=[CH:10][C:5]([C:6]([O:8][CH3:9])=[O:7])=[CH:4][CH:3]=1.C(=O)([O-])[O-].[K+].[K+].[CH2:18](Br)[C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1>CC(C)=O>[CH3:9][O:8][C:6](=[O:7])[C:5]1[CH:4]=[CH:3][C:2]([O:1][CH2:18][C:19]2[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=2)=[CH:11][CH:10]=1

参加物

5

反応物 3

HCID 7456MethylparabenHCID 7498Benzyl BromideHCID 11430Potassium Carbonate

生成物 1

HCID 299810Methyl 4-(benzyloxy)benzoate収率 100.1%

試薬・触媒・溶媒 1

HCID 180Acetone溶媒

反応条件

温度
50 °C

実験手順

A mixture of methyl 4-hydroxy-benzoate (10.0 g, 0.066 mol) and potassium carbonate (12 g, 0.086 mol), were taken in acetone (50 ml) and heated at 50° C. for 1 hour. To the reaction mixture benzyl bromide (8.2 ml, 0.072 mol) was added. The mixture was heated at 80° C. for 5 hours. The mixture was cooled to room temperature and filtered through sintered funnel, washed with acetone. Solvent was removed to obtain pure 4-benzyloxy-benzoic acid methyl ester as white solid (16 g, 100%).

後処理

  1. temperatureThe mixture was heated at 80° C. for 5 hours
  2. temperatureThe mixture was cooled to room temperature
  3. filtrationfiltered through sintered funnel
  4. washwashed with acetone
  5. customSolvent was removed

出典と根拠

ORDレコード
ord-5a3d3e03777448dfa5c9178a4ea936f8
出典データセット
uspto-grants-2014_10
特許番号
US08859566B2

関連ノート

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