2-Amino-4-methyl-3-nitropyridine → 4-Methylpyridine-2,3-diamine

HRID 53601

反応式

HRID 53601 の反応式
[NH2:1][C:2]1[C:7]([N+:8]([O-])=O)=[C:6]([CH3:11])[CH:5]=[CH:4][N:3]=1>[Ni].C(O)C>[NH2:1][C:2]1[C:7]([NH2:8])=[C:6]([CH3:11])[CH:5]=[CH:4][N:3]=1

参加物

4

反応物 1

HCID 2431662-Amino-4-methyl-3-nitropyridine

生成物 1

HCID 3174954-Methylpyridine-2,3-diamine収率 100.1%

試薬・触媒・溶媒 2

HCID 935Nickel触媒HCID 702Ethanol溶媒

実験手順

A mixture of 2-amino-4-methyl-3-nitropyridine (919 mg, 6.0 mmol), ethanol (20 mL) and Raney Ni (about 200 mg) was shaken under H2 (30-40 psi) for 1 h, then filtered. The filtrate was evaporated to dryness, giving 740 mg (100%) of the diamine 56, mp 114°-5° C. 1H NMR (DMSO-d6), 1.997 (s, 3H), 4.359 (s, 2H), 5.250 (s, 2H), 6.264 (d, 1H, J=3), 7.173 (d, 1H, J=3).

後処理

  1. filtrationfiltered
  2. customThe filtrate was evaporated to dryness

出典と根拠

ORDレコード
ord-972228a99c6b4092b37618fa57402f8d
出典データセット
uspto-grants-1997_04
特許番号
US05620978

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