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Cesium carbonate → Tert-butyl {4-[4-(4-methoxybenzylamino)-3-(3-methoxyphenyl)pyrrolo[3,2-c]pyridin-1-yl]butyl)carbamate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Cesium carbonate | HCID 10796 | — |
| 反応物 | tert-butyl N-(4-bromobutyl)carbamate | HCID 10868765 | — |
| 反応物 | (4-methoxybenzyl)-(3-(3-methoxyphenyl)-1H-pyrrolo-[3,2-c]pyridin-4-yl]amine | HCID 59765091 | — |
| 溶媒 | Dimethylformamide | HCID 6228 | — |
| 生成物 | Tert-butyl {4-[4-(4-methoxybenzylamino)-3-(3-methoxyphenyl)pyrrolo[3,2-c]pyridin-1-yl]butyl)carbamate | HCID 59765096 | 102.8% |
反応手順
450 mg (1.1 mmol) of (4-methoxybenzyl)-[3-(3-methoxyphenyl)-1H-pyrrolo-[3,2-c]pyridin-4-yl]amine from Example B3, 428 mg (1.7 mmol) of 4-(BOC-amino)butyl bromide and 0.9 g (2.8 mmol) of caesium carbonate in 60 ml of DMF are warmed to 60° C. over the course of 12 h. Aqueous work-up at RT and chromatographic purification gives 600 mg (82%) of a colourless oil.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08859581B2 |
| 出典データセット | uspto-grants-2014_10 |
| ORD ID | ord-56aef82dd0ec4eaf9807051269131f47 |
| 出典メモ | uspto-grants-2014_10 |