化工社化工社 化学情報印刷レポート · 研究参考用
(2,6-Dichlorophenyl)acetonitrile → 6-(2,6-Dichlorophenyl)pyrido[2,3-d]pyrimidine-2,7-diamine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | (2,6-Dichlorophenyl)acetonitrile | HCID 76678 | — |
| 反応物 | 2,4-Diaminopyrimidine-5-carbaldehyde | HCID 309176 | — |
| 反応物 | Sodium | HCID 5360545 | — |
| 反応物 | Sodium 2-ethoxyethoxide | HCID 23667900 | — |
| 溶媒 | Glycol monoethyl ether | HCID 8076 | — |
| 生成物 | 6-(2,6-Dichlorophenyl)pyrido[2,3-d]pyrimidine-2,7-diamine | HCID 5328113 | — |
反応手順
(Prepared by the method of U.S. Pat. No. 3,534,039). To a solution of sodium 2-ethoxyethoxide prepared from 0.14 g of sodium and 60 mL of 2-ethoxyethanol was added 2.07 g of 2,4-diamino-5-pyrimidinecarboxaldehyde, and 2.79 g of 2,6-dichlorophenylacetonitrile. The mixture was heated at reflux for 4 hours, allowed to cool to room temperature, and the precipitated product was filtered and washed with diethyl ether to give 2,7-diamino-6-(2,6-dichlorophenyl)-pyrido[2,3-d]-pyrimidine, mp 325°-332° C.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05620981 |
| 出典データセット | uspto-grants-1997_04 |
| ORD ID | ord-7c49ec69efa1441294b8a70783be63e8 |
| 出典メモ | uspto-grants-1997_04 |