Bromine → HCID 44512476、化合物
反応式
[CH3:1][O:2][C:3]1[CH:4]=[CH:5][C:6]([CH3:13])=[C:7]([NH:9][C:10](=[O:12])[CH3:11])[CH:8]=1.[Br:14]Br>C(O)(=O)C>[Br:14][C:4]1[C:3]([O:2][CH3:1])=[CH:8][C:7]([NH:9][C:10](=[O:12])[CH3:11])=[C:6]([CH3:13])[CH:5]=1参加物
4
反応条件
- 温度
- 50 °C
実験手順
To a solution of N-(5-methoxy-2-methylphenyl)acetamide in acetic acid (40 mL) was added Br2 (3 g, 19 mmol) slowly. The mixture was capped and stirred at 50° C. for 5 hours. The reaction was cooled to room temperature, then quenched with sodium sulfite aqueous solution, and extracted with ethyl acetate (3×50 mL). The combined organic layer was dried over Na2SO4 and concentrated to give crude N-(4-bromo-5-methoxy-2-methylphenyl)acetamide as a brown oil, which was used in the next step without further purification.
後処理
- customThe mixture was capped
- temperatureThe reaction was cooled to room temperature
- customquenched with sodium sulfite aqueous solution
- extractionextracted with ethyl acetate (3×50 mL)
- dry with materialThe combined organic layer was dried over Na2SO4
- concentrationconcentrated
出典と根拠
- ORDレコード
- ord-96417e96e1eb469a852db45b07a0aceb
- 出典データセット
- uspto-grants-2014_10
- 特許番号
- US08859574B2
反応ノート
読み込み中…