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Methanol → 4-amino-2,3-dihydro-1H-inden-2-ol
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Methanol | HCID 887 | — |
| 反応物 | Potassium Carbonate | HCID 11430 | — |
| 反応物 | 4-amino-2,3-dihydro-1H-inden-2-yl acetate | HCID 13239584 | — |
| 溶媒 | Isopropanol | HCID 3776 | — |
| 生成物 | 4-amino-2,3-dihydro-1H-inden-2-ol | HCID 54595426 | 99% |
反応手順
A slurry of 4-amino-2,3-dihydro-1H-inden-2-yl acetate (12.6 g, 65.9 mmol; prepared according to US2003109700), MeOH (63 mL), and potassium carbonate (13.7 g, 99.0 mmol) was stirred at ambient temperature for 15 minutes. The reaction mixture was diluted with IPA (630 mL), passed through a plug of silica gel, washed with IPA (100 mL), and concentrated to give the title compound (9.70 g, 65.0 mmol, 99%). MS (DCI) m/z 267 (M+NH4)+.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08859584B2 |
| 出典データセット | uspto-grants-2014_10 |
| ORD ID | ord-228c365d383e4ceba0442cb320284762 |
| 出典メモ | uspto-grants-2014_10 |