Ammonia → 5-fluoro-1-(2-fluorobenzyl)-1H-pyrazolo(3,4-b)pyridine-3-carboxamide
反応式
C([O:3][C:4]([C:6]1[C:14]2[C:9](=[N:10][CH:11]=[C:12]([F:15])[CH:13]=2)[N:8]([CH2:16][C:17]2[CH:22]=[CH:21][CH:20]=[CH:19][C:18]=2[F:23])[N:7]=1)=O)C.[NH3:24]>CO>[F:15][C:12]1[CH:13]=[C:14]2[C:6]([C:4]([NH2:24])=[O:3])=[N:7][N:8]([CH2:16][C:17]3[CH:22]=[CH:21][CH:20]=[CH:19][C:18]=3[F:23])[C:9]2=[N:10][CH:11]=1参加物
4
実験手順
1.00 g (3.152 mmol) of the compound obtained in example 8A was stirred in 10 ml of a 7N solution of ammonia in methanol at RT for three days. Then it was concentrated by vacuum evaporation. 908 mg (99% of theor.) of the title compound was obtained.
後処理
- concentrationThen it was concentrated by vacuum evaporation
出典と根拠
- ORDレコード
- ord-deb44306dd234f52adabe93f4ad3f7c8
- 出典データセット
- uspto-grants-2014_10
- 特許番号
- US08859569B2
反応ノート
読み込み中…