5-Methoxy-3-methoxycarbonylmethyl-indan-1-yl-ammonium chloride → 3-Carboxymethyl-5-methoxy-indan-1-yl-ammonium chloride

HRID 536637ノート

反応式

HRID 536637 の反応式
[Cl-:1].[CH3:2][O:3][C:4]1[CH:5]=[C:6]2[C:10](=[CH:11][CH:12]=1)[CH:9]([NH3+:13])[CH2:8][CH:7]2[CH2:14][C:15]([O:17]C)=[O:16]>Cl>[Cl-:1].[C:15]([CH2:14][CH:7]1[C:6]2[C:10](=[CH:11][CH:12]=[C:4]([O:3][CH3:2])[CH:5]=2)[CH:9]([NH3+:13])[CH2:8]1)([OH:17])=[O:16]

参加物

3

反応物 1

HCID 866562075-Methoxy-3-methoxycarbonylmethyl-indan-1-yl-ammonium chloride

生成物 1

HCID 866562083-Carboxymethyl-5-methoxy-indan-1-yl-ammonium chloride

試薬・触媒・溶媒 1

HCID 313Hydrochloric Acid溶媒

実験手順

5-Methoxy-3-methoxycarbonylmethyl-indan-1-yl-ammonium chloride (12.5 g) dissolved in 2 M hydrochloric acid (120 mL) is stirred at reflux temperature for 3 h. Then, the solvent is removed and the residue is azeotropically dried using toluene and further purified by washing with diisopropylether. The product is dried at 50° C.

後処理

  1. temperatureat reflux temperature for 3 h
  2. customThen, the solvent is removed
  3. customthe residue is azeotropically dried
  4. customfurther purified
  5. washby washing with diisopropylether
  6. customThe product is dried at 50° C.

出典と根拠

ORDレコード
ord-ed0e7ba0c73f46d5824860b0d3267361
出典データセット
uspto-grants-2014_10
特許番号
US08859580B2

反応ノート

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