N'-(3-butyl-5-tert-butyl-1,3,4-thiadiazol-3-ium-2-yl)-N,N-dimethylmethanimidamide bromide → 5-Tert-butyl-3-butyl-1,3,4-thiadiazol-2(3h)-imine
反応式
[Br-].[C:2]([C:6]1[S:10][C:9](/[N:11]=C/N(C)C)=[N+:8]([CH2:16][CH2:17][CH2:18][CH3:19])[N:7]=1)([CH3:5])([CH3:4])[CH3:3]>Cl>[C:2]([C:6]1[S:10][C:9](=[NH:11])[N:8]([CH2:16][CH2:17][CH2:18][CH3:19])[N:7]=1)([CH3:5])([CH3:4])[CH3:3]参加物
3
実験手順
A solution of Example 162B (4 g, 11.45 mmol) in 1N HCl (12.6 mL) was heated at 65° C. for 12 hours. The mixture was cooled at room temperature and extracted with ether (2×20 mL). The aqueous phase was neutralized to pH 7 with concentrated ammonia and extracted with ether (2×25 mL). The combined organic extracts were dried over MgSO4, filtered, and concentrated under reduced pressure. The residue was purified by chromatography on SiO2 using an Analogix® Intelliflash280™ (Hexanes-EtOAc: 0-80%) to give the title compound. LC/MS m/z 214 (M+H)+.