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Triethylamine → 2-[4-(3-Oxo-1,2-benzothiazol-2-yl)phenyl]acetic acid
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Triethylamine | HCID 8471 | — |
| 反応物 | 4-Aminophenylacetic acid | HCID 14533 | — |
| 反応物 | 2-(Chlorothio)-benzoyl chloride | HCID 10910715 | — |
| 溶媒 | Glycol monoethyl ether | HCID 8076 | — |
| 生成物 | 2-[4-(3-Oxo-1,2-benzothiazol-2-yl)phenyl]acetic acid | HCID 462937 | 69.4% |
反応手順
To a mixture of 7.55 g (0.05 mol) of 4-aminophenylacetic acid and 15.15 g (0.15 mol) of triethylamine in 25 mL of ethyl cellosolve was added 10.3 g (0.05 mol) of 2-chlorosulfenylbenzoyl chloride (Arzneimittel Forsch., 1964;14:1301) . The mixture was stirred at room temperature for 3 hours, concentrated in vacuo, and water was added to the residue. The mixture was acidified with HCl and filtered to give 9.9 g of the title compound, mp 173°-175° C.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05620997 |
| 出典データセット | uspto-grants-1997_04 |
| ORD ID | ord-19bbb259259440cc8353ec428272db43 |
| 出典メモ | uspto-grants-1997_04 |