Hydrochloric Acid → 3,4-Dimethoxybicyclo[4.2.0]octa-1,3,5-trien-7-one
反応式
C([O:3][C:4]1(OCC)[CH2:11][C:10]2[C:5]1=[CH:6][C:7]([O:14][CH3:15])=[C:8]([O:12][CH3:13])[CH:9]=2)C.Cl.O>C1COCC1.O>[CH3:13][O:12][C:8]1[CH:9]=[C:10]2[C:5](=[CH:6][C:7]=1[O:14][CH3:15])[C:4](=[O:3])[CH2:11]2参加物
5
実験手順
7,7-Diethoxy-3,4-dimethoxybicyclo[4.2.0]octa-1,3,5-triene (1.76 g, 6.98 mmol) is stirred in a mixture of THF/water (6/1) at ambient temperature. 815 mg of an aqueous 11N HCl solution (1.1 eq, 7.7 mmol) are then added. The reaction mixture is stirred for 2 hours ambient temperature. Water is added to facilitate two extractions with ethyl acetate (2×30 mL). The organic phases are dried over MgSO4 and then subjected to drying. There are obtained 1.01 g of the title product in the form of a grey powder.
後処理
- extractiontwo extractions with ethyl acetate (2×30 mL)
- dry with materialThe organic phases are dried over MgSO4
- customto drying
出典と根拠
- ORDレコード
- ord-a55c9872dcac49f7952bb584fe88330a
- 出典データセット
- uspto-grants-2014_10
- 特許番号
- US08859763B1
反応ノート
読み込み中…