hydroxylamine-O-sulfonic acid → 1-Amino-5,7-dichloro-1,4-dihydro-2,3-quinoxalinedione

HRID 53747

反応式

HRID 53747 の反応式
[Cl:1][C:2]1[CH:11]=[C:10]([Cl:12])[CH:9]=[C:8]2[C:3]=1[NH:4][C:5](=[O:14])[C:6](=[O:13])[NH:7]2.[NH2:15]OS(O)(=O)=O>[OH-].[K+].O>[NH2:15][N:7]1[C:8]2[C:3](=[C:2]([Cl:1])[CH:11]=[C:10]([Cl:12])[CH:9]=2)[NH:4][C:5](=[O:14])[C:6]1=[O:13]

参加物

5

反応物 2

HCID 76284hydroxylamine-O-sulfonic acidHCID 6502605,7-Dichloro-1,4-dihydroquinoxaline-2,3-dione

生成物 1

HCID 199586181-Amino-5,7-dichloro-1,4-dihydro-2,3-quinoxalinedione収率 69%

試薬・触媒・溶媒 2

HCID 962Water溶媒HCID 14797Potassium Hydroxide溶媒

反応条件

温度
60 °C

実験手順

The procedure of Wallace, R. G., Org. Prep. Proc. Int. 14: 269 (1982) was adapted. 5,7-Dichloro-1,4-dihydroquinoxaline-2,3-dione (52 mg, 0.225 mmole) was dissolved in 3N KOH (1 mL) at 60° C. for 0.5 h, and NH2OSO3H (30 mg, 0.265 mmole, Aldrich) in distilled water (0.5 mL) was dropwise added into above solution with stirring at 60° C. Some precipitate came out after 15 mins. The mixture was stirred at room temperature overnight. The white precipitate was collected by filtration, washed with cold distilled water (0.5 mL) and dried on rotavapor at 60° C. for 2 h affording crude 1-amino-5,7-dichloro-1,4-dihydro-2,3-quinoxalinedione (38 mg, 69%), which included a little of the isomer (4-amino-5,7-dichloro-2,3-quinoxalinedione) by 1H NMR (it is not known which isomer is present in a greater amount).

後処理

  1. stirringThe mixture was stirred at room temperature overnight
  2. filtrationThe white precipitate was collected by filtration
  3. washwashed
  4. distillationwith cold distilled water (0.5 mL)
  5. customdried on rotavapor at 60° C. for 2 h

出典と根拠

ORDレコード
ord-4c5d952d5e704bfdac91a8ae748464b9
出典データセット
uspto-grants-1997_04
特許番号
US05620979

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