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Dicyclohexylcarbodiimide → N,N'-Dicyclohexylurea
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Dicyclohexylcarbodiimide | HCID 10868 | — |
| 反応物 | monoMethyl adipate | HCID 12328 | — |
| 反応物 | N-Hydroxysuccinimide | HCID 80170 | — |
| 触媒 | 4-(Dimethylamino)pyridine | HCID 14284 | — |
| 溶媒 | Dimethylformamide | HCID 6228 | — |
| 生成物 | N,N'-Dicyclohexylurea | HCID 4277 | — |
反応手順
Step 1, Compound 4: Adipic acid monomethyl ester is treated with one molar equivalent of DCC, DMAP and N-hydroxysuccinimide in DMF for 30 min. To this a molar equivalent of the compound obtained from Step 3a (Example 1) is added and stirred at ambient temperature for 8 h. Dicylcohexylurea formed during the course of the reaction is filtered off and the product is extracted into ethyl acetate, washed with sodium bicarbonate solution followed by standard workup. The methyl ester thus obtained is treated with LiOH in THF/water to obtain compound 4.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08865677B2 |
| 出典データセット | uspto-grants-2014_10 |
| ORD ID | ord-f1cf80c97c0745ac99ef57d6f3b6c1ab |
| 出典メモ | uspto-grants-2014_10 |