Acetic Anhydride → N-(4-fluoro-2-(trifluoromethyl)phenyl)acetamide

HRID 53775

反応式

HRID 53775 の反応式
[NH2:1][C:2]1[CH:7]=[CH:6][C:5]([F:8])=[CH:4][C:3]=1[C:9]([F:12])([F:11])[F:10].[C:13](OC(=O)C)(=[O:15])[CH3:14]>>[C:13]([NH:1][C:2]1[CH:7]=[CH:6][C:5]([F:8])=[CH:4][C:3]=1[C:9]([F:12])([F:10])[F:11])(=[O:15])[CH3:14]

参加物

3

反応物 2

HCID 7918Acetic AnhydrideHCID 678534-Fluoro-2-(trifluoromethyl)aniline

生成物 1

HCID 10560920N-(4-fluoro-2-(trifluoromethyl)phenyl)acetamide収率 98%

実験手順

A solution of 2-amino-5-fluorobenzotrifluoride (2.025 g, 11.31 mmol, Aldrich) in acetic anhydride (10 mL) was stirred at room temperature for 12 h, and then most of the acetic anhydride was removed. The white needle crystals were collected by filtration, affording 2.445 g (98%) of 2-acetamido-5-fluorobenzotrifluoride. 1H NMR (CDCl3): δ 2.205 (S, 3H); 7.229-7.335 (m, 3H); 8.055 (dd, 1H, J1 =4.8 Hz, J2 =8.4 Hz).

後処理

  1. custommost of the acetic anhydride was removed
  2. filtrationThe white needle crystals were collected by filtration

出典と根拠

ORDレコード
ord-a4fc415634834fa4b50ffb1937ce7782
出典データセット
uspto-grants-1997_04
特許番号
US05620979

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