Dimethylamine → Ethyl 6-(dimethylamino)hexanoate
反応式
CS([CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][C:10]([O:12][CH2:13][CH3:14])=[O:11])(=O)=O.[CH3:15][NH:16][CH3:17]>C(O)C>[CH3:15][N:16]([CH3:17])[CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][C:10]([O:12][CH2:13][CH3:14])=[O:11]参加物
4
実験手順
Ethyl 6-(methanesulfonyl)hexanoate was allowed to react in a 5.6M solution of dimethylamine in ethanol (100 mL) for 17 hours. The solution was then concentrated in vacuo to dryness. The resulting bright orange paste was purified by column chromatography (column 5″L×2″W; eluted with a gradient of 100% dichloromethane→1%/0.25%→2%/0.5% MeOH/NH4OH in dichloromethane) to afford the product as a yellow oil.
後処理
- concentrationThe solution was then concentrated in vacuo to dryness
- customThe resulting bright orange paste was purified by column chromatography (column 5″L×
- washeluted with a gradient of 100% dichloromethane→1%/0.25%→2%/0.5% MeOH/NH4OH in dichloromethane)
出典と根拠
- ORDレコード
- ord-8d0206cdf00141ef8a30efbdd0e81347
- 出典データセット
- uspto-grants-2014_10
- 特許番号
- US08865675B2
反応ノート
読み込み中…