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HRID 537857作成日：2026年10月25日
N-(3-Aminophenyl)methanesulfamide → tert-butyl 2-(2-((3-(methylsulfonamido) phenyl)amino)oxazol-5-yl)-1H-indole-1-carboxylate
https://huagongshe.com/reaction/537857
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | N-(3-Aminophenyl)methanesulfamide | HCID 2734262 | — |
| 反応物 | tert-butyl 2-(2-chlorooxazol-5-yl)-1H-indole-1-carboxylate | HCID 71060197 | — |
| 溶媒 | Isopropanol | HCID 3776 | — |
| 生成物 | tert-butyl 2-(2-((3-(methylsulfonamido) phenyl)amino)oxazol-5-yl)-1H-indole-1-carboxylate | HCID 71060239 | 54% |
反応手順
A mixture of tert-butyl 2-(2-chlorooxazol-5-yl)-1H-indole-1-carboxylate 21 (0.281 g, 0.883 mmol) and commercially available N-(3-aminophenyl)methanesulfonamide 6 (0.321 g, 1.723 mmol) in 2-propanol (20 mL) was heated to 80° C. for 14 h with stirring. Upon cooling, solvent was evaporated and silica column purified (Biotage) (Acetone/hexane as an eluent) to provide tert-butyl 2-(2-((3-(methylsulfonamido) phenyl)amino)oxazol-5-yl)-1H-indole-1-carboxylate 24 (0.221 g, 54% yield) as solid. MS (ES) m/z 469 (M+H+).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| 特許番号 | US08865709B2 |
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| 出典データセット | uspto-grants-2014_10 |
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| ORD ID | ord-da04752b604f471ca476c8cefccdfde2 |
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| 出典メモ | uspto-grants-2014_10 |
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