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HRID 537864作成日：2026年10月24日
N-(3-Aminophenyl)methanesulfamide → N-(3-((5-(4-(trifluoromethyl)phenyl)oxazol-2-yl)amino)phenyl) methane sulfonamide
https://huagongshe.com/ja/reaction/537864
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | N-(3-Aminophenyl)methanesulfamide | HCID 2734262 | — |
| 反応物 | 2-Chloro-5-(4-(trifluoromethyl)phenyl)oxazole | HCID 71060395 | — |
| 溶媒 | Isopropanol | HCID 3776 | — |
| 生成物 | N-(3-((5-(4-(trifluoromethyl)phenyl)oxazol-2-yl)amino)phenyl) methane sulfonamide | HCID 71060442 | 41% |
反応手順
A mixture of 2-chloro-5-(4-(trifluoromethyl)phenyl)oxazole 31 (0.599 g, 2.42 mmol) and commercially available N-(3-aminophenyl)methanesulfonamide 6 (0.451 g, 2.42 mmol) in 2-propanol (20 mL) was heated to 80° C. for 14 h with stirring. Upon cooling, solvent was evaporated and silica column purified (Biotage) (Acetone/hexane as an eluent) to provide N-(3-((5-(4-(trifluoromethyl)phenyl)oxazol-2-yl)amino)phenyl) methane sulfonamide 33 (0.393 g, 41% yield) as a solid. MS (ES) m/z 398 (M+H+).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| 特許番号 | US08865709B2 |
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| 出典データセット | uspto-grants-2014_10 |
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| ORD ID | ord-168bbfb1619c43dfbb3c7a38f0e41240 |
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| 出典メモ | uspto-grants-2014_10 |
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